systemic lupus erythematosus

from The American Heritage® Dictionary of the English Language, 5th Edition.

• noun An inflammatory, multisystemic, autoimmune disease of the connective tissue, characterized by fever, skin lesions, joint pain or arthritis, and anemia, and often affecting the kidneys, spleen, and various other organs.

from Wiktionary, Creative Commons Attribution/Share-Alike License.

• proper noun healthcare A systemic autoimmune disease (or autoimmune connective tissue disease), where the immune system attacks the body's cells and tissue that causes inflammation and tissue damage.

from WordNet 3.0 Copyright 2006 by Princeton University. All rights reserved.

• noun an inflammatory disease of connective tissue with variable features including fever and weakness and fatigability and joint pains and skin lesions on the face or neck or arms